Endolysosomal transport in cellular signaling
Organelles utilize specific identity markers to orchestrate membrane trafficking..
Endosomal maturation involves changes in membrane identity, centered around the Rab7-guanine nucleotide exchange factor complex Mon1-Ccz1, which functions on endosomes or autophagosomes.
Studies of Golgi–guanine nucleotide exchange factors suggest that Rab activation also relies on the recognition of their hypervariable domain—a mechanism potentially relevant in other pathways and highlighting the lack of knowledge in the fine-tuning of Rab activation.
Structural analyses of endosomal tethering complexes revealed the basis for tethering and fusion of endosomes, implying principles potentially also important to other trafficking pathways.
Recent insights indicate that membranous structures budding from the vacuole are involved in signaling endosome formation and target of rapamycin complex–dependent signaling, which require both the Fab1 and the HOPS (homotypic fusion and vacuole protein sorting) complexes.
This marks the crossroads between cellular signaling of metabolic or environmental cues and membrane trafficking pathways.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00266-1
