IL-22 in metabolic health
Interleukin-22 (IL-22) maintains metabolic homeostasis by impacting glucose and lipid metabolism.
IL-22 signaling in the pancreas, liver, intestine, and skin enhances pancreatic beta-cell function, supports liver regeneration, maintains intestinal barrier integrity, and influences skin cell proliferation and wound healing.
IL-22-based therapies show potential for type 2 diabetes, obesity, polycystic ovary syndrome, and metabolic dysfunction-associated steatotic liver disease by improving insulin secretion, cellular proliferation/regeneration, reducing inflammation, and mitigating hepatic steatosis.
Targeting IL-22 signaling pathways in specific tissues offers a nuanced approach to maximize benefits while minimizing adverse effects.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(24)00283-1
https://sciencemission.com/Harnessing-IL-22-for-metabolic-health:-promise-and-pitfalls
