Iron-dependent enteric neurodegeneration from western diet
High in saturated fats such as palmitic acid (PA), present in western diets (WD) promote enteric neurodegeneration and motility disorders.
The researchers evaluated if WD and PA drive iron-dependent ferroptotic injury in the enteric nervous system using different model systems.
The authors observed disrupted neurotransmitter signaling, reduced mitochondrial and antioxidant programs, and increased iron import and lipid peroxidation signatures in western diet treated animal models.
They also found PA increased labile iron, mitochondrial ROS, membrane depolarization, Ca2+ dysregulation.
In humans, PA induced enteric neuronal iron loading and ferroptosis, supporting translational relevance to diet-associated enteric neuropathy.
https://www.jci.org/articles/view/196113
https://sciencemission.com/Western-diet-induces-iron-dependent-enteric-nd
