Noninvasive brain stimulation induced plasticity and metaplasticity
Noninvasive brain stimulation (NIBS) can induce brain plasticity and metaplasticity, offering therapeutic potential across neurological and psychiatric conditions.
NIBS-induced effects are shaped not only by stimulation parameters but also by baseline neural states and recent activities, reflecting the dynamic nature of synaptic responsiveness.
This review synthesizes how NIBS protocols evoke long-term potentiation (LTP)- like and long-term depression (LTD)-like effects, and how the expression of these effects is regulated through metaplastic principles.
Exploring the interplay of sequential or combined NIBS protocols may reveal novel insights into metaplasticity, though individual variability remains a major translational challenge.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00151-1
