Protecting against neuro-inflammation with cellular rejuvenation
Neuronal inflammation leads to demyelination, neuroaxonal injury, and cell death in multiple sclerosis (MS) but the mechanism is not clearly understood.
The researchers in this study describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis.
Partial reprogramming with adeno-associated virus (AAV2)-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00069-5
https://sciencemission.com/Cellular-rejuvenation-protects-neurons
