Rectal cancer organoids to predict patient responses to chemoradiation
Rectal cancer organoids (RCO) could be a useful model to predict patients clinical outcome..
The researchers in this study establish a rectal cancer organoid biobank and demonstrate its high accuracy in predicting clinical response.
They highlight time-dependent predictive accuracy of organoid assays, uncover synergistic or antagonistic effects of combined chemoradiation,.
The researchers also identify irinotecan as a promising neoadjuvant agent, providing valuable insights for organoid-guided precision oncology.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00470-7
