Repeat expansion diseases impacted by interruptions?

Interruptions impact the clinical manifestation of repeat expansion diseases. 

Interruptions are dynamic, being gained and lost within a single generation.

They are not random, showing locus specificity and occurring seemingly more often nearer to flanking sequences.

How interruptions are gained and lost is not known.

The researchers propose that synthesis-dependent microhomology-mediated end joining accounts for most, if not all, documented interruptions.

https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00169-6

https://sciencemission.com/Interruptions-impact-clinical-features-of-repeat-expansion-diseases