Myelin development disorder in SLC44A1 deficient mice
Normal brain requires the wrapping of axons with myelin sheath for the smooth transmission of neural signals. Mechanism underlying demyelination in various neurodevelopmental disorders is not yet clear.
The researchers show that oligodendrocyte enriched human solute carrier 44A1 (SLC44A1) is essential for CNS myelination by supporting choline metabolism and phosphatidylcholine synthesis.
The authors show that loss of SLC44A1 impairs oligodendrocyte maturation and myelin formation, while citicoline, a natural choline metabolite, supplementation rescues these defects, offering a therapeutic strategy for SLC44A1-related myelin disorders.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01389-0
