Neuronal size impact nervous system development
Neuronal size alterations have been associated with neurodevelopmental and degenerative diseases. It is not clear how neuron cell body and neurite size and organization impact nervous system development and function.
The researchers in this study used triploid Xenopus with 1.5-fold increase in genome size compared with diploids as a model to characterize effects of neuron size on vertebrate nervous system development and function.
The authors demonstrate an increase in total volume and membrane surface area in triploids and were morphologically and transcriptionally similar to diploid brains but less proliferative, containing fewer neurons and displaying increased global activity.
In addition, neuron size increase in triploids was associated with altered animal swimming behavior.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00047-1
https://sciencemission.com/Ploidy-and-neuron-size-impact-nervous-system
