Sex dependent alteration in Alzheimer’s pathology

Aβ triggers p-tau secretion in Alzheimer’s disease (AD) that drives tau aggregation and  thus identifying  modulators of Aβ-related p-tau increases may help with the therapeutics.

This study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy.

The researchers found that only sex but not age, sTREM2-related microglial activation or ApoE4 modulated the Aβ to p-tau axis.

They show that higher sTREM2-related microglial activation and ApoE4 positivity were linked to elevated p-tau levels, with stronger associations in women than in men.

Female sex is associated with a stronger Aβ-dependent p-tau secretion, potentially driven by elevated sTREM2-related microglial activation.

https://www.embopress.org/doi/full/10.1038/s44321-024-00190-3

https://sciencemission.com/Female-sex-in-Alzheimer%E2%80%99s-disease