Glymphatics and meningeal lymphatics unlock the brain-immune code
Recent evidence suggest meningeal lymphatic vessels clear the waste from deep within the CNS.
The presentation of brain-derived self-peptides emerges at the brain’s borders and drives T cell responses with suppressive properties, critical in allowing active immunosurveillance while limiting aberrant immune reactivity.
The authors also discuss how inflammation, aging, and neurodegenerative diseases potentially reshape the repertoire of self-antigens and immune cells, disrupting the healthy dialogue between the CNS and immune system.
They also evaluate the new therapeutic avenues for CNS pathologies.
https://www.cell.com/immunity/fulltext/S1074-7613(25)00125-6
