ER exit site regulation by post-translational modifications

Endoplasmic reticulum exit sites are dynamic hubs that integrate protein trafficking, quality control, and signaling rather than static export platforms. 

Post-translational modifications of coat protein complex II and other proteins rapidly and reversibly tune endoplasmic reticulum exit sites’ organization and function in response to cellular cues.

Post-translational modifications regulate endoplasmic reticulum exit sites’ biogenesis and liquid–liquid phase separation, linking signaling pathways to structural remodeling of the early secretory pathway.

Diverse post-translational modifications control cargo-specific transport from the endoplasmic reticulum, including specialized mechanisms for large cargos and selective client sorting.

Emerging roles for post-translational modifications extend endoplasmic reticulum exit sites/coat protein complex II functions to autophagy, endoplasmic reticulum-specific autophagy, and disease-relevant signaling pathways, highlighting their importance to cellular homeostasis.
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https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00159-5
https://sciencemission.com/Remaking-an-exit