Protein codes and mobility together shape cellular function and disease
Proteins encode not only folding instructions, but also distribution codes that dictate selective partitioning into chemically distinct compartments.
Compartmental solvation environments act as filters that sculpt proteome composition, small-molecule access, and reaction specificity.
Protein mobility within and across condensates is essential for sustaining collision-limited biochemistry, yet is highly variable and context dependent.
Proteolethargy, the pathological reduction of protein mobility under oxidative stress, emerges as a unifying mechanism across chronic diseases.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00250-6
