The striatal dopamine system in schizophrenia
Techniques for characterising the mesostriatal dopamine system, both in humans and animal models, have advanced significantly over the past decade.
In vivo imaging studies in schizophrenia patients demonstrate that dopaminergic dysfunction in schizophrenia is greatest in nigrostriatal as opposed to mesolimbic pathways.
Better understanding of striatal structure and function has enhanced our insight into the neurobiological basis of psychotic symptoms.
The role of other neurotransmitters in modulating striatal dopamine function merits further exploration, and modulating these neurotransmitter systems has potential to offer new therapeutic strategies.
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(18)30317-5
