Roles of lysosomal small-molecule transporters in metabolism and signaling

Small-molecule transporters of the lysosomal membrane export lysosomal catabolites for reuse in cell metabolism. 

These transporters often show substrate promiscuity and, conversely, a given metabolite is often exported through distinct transport routes and sometimes in different states (e.g., single amino acids versus dipeptides).

Some lysosomal transporters import metabolites into the lumen. The combination of importers and exporters can create small-molecule shuttles across the lysosomal membrane, which regulate the lumen state.

Some lysosomal transporters participate in intracellular signaling cascades.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00222-3

https://sciencemission.com/lysosomal-small-molecule-transporters