Cytoplasmic DNA sensors and their regulators
Mitochondria and nucleus contain mitochondrial-DNA and nuclear-DNA respectively and their presence outside these compartments, in the cytoplasm, constitute damage-associated molecular patterns (DAMP) that trigger innate immune responses.
DAMPs interact with wide variety of proteins and molecules that act as sensors or regulators to manage inflammatory responses within a given cell or tissue.
The authors In this review, describe the various DNA substrates that co-exist in cells, how they are sensed, and what regulates their cytoplasmic availability and recognition.
The authors describe the tissue-specific immune response and therapeutic intervention to treat inflammatory pathologies.
https://www.sciencedirect.com/science/article/pii/S2319417026000442
