Lipids in age-related lens disease
The specific lipid makeup of lens fiber cell membranes plays a critical role in maintaining lens structure and function.
The lens lipidome changes with age and age-related disease development, with the most prominent changes occurring in glycerophospholipid, dihydrosphingomyelin, and cholesterol pathways.
Recent advances in lipidomic analysis techniques have enabled researchers to obtain a more complete characterization of the lens lipidome under normal and disease conditions.
The ongoing development of lipid centered pharmacological therapy for age-related lens disease highlights the potential for the reversal of age-related changes in the lens lipidome, which could cure cataract and presbyopia.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(25)00270-6
