MicroRNAs in neurodegenerative diseases

Neurodegenerative diseases (NDDs) are ranked amongst the leading causes of death worldwide, surpassing even cancer according to some recent estimates. 

The study of NDDs through the unifying lens of their common hallmarks is essential in identifying and treating the underlying causes, rather than the symptoms, of NDDs.

Given the anatomical isolation of the central nervous system (CNS) from the vascular system, with only a few specialized structures of direct exchange with the rest of the body, it is imperative to consider CNS architecture to better understand NDDs.

The interdependent, mutually reinforcing nature of the NDD hallmarks makes miRNAs, with their pleiotropic action, especially suitable to treat NDDs.

Emerging preclinical studies in mouse models of NDDs have demonstrated the efficacy of miRNAs in resolving the underlying biological causes as well as the symptoms of these diseases.

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https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00057-7
https://sciencemission.com/MicroRNAs-in-NDD