Brain endocannabinoid signaling in behaving animals
A wide range of physiological phenomena are controlled by brain’s endocannabinoid signaling system.
Although molecular machinery underlying endocannabinoid-mediated synaptic signaling have been well defined, short-lived nature of endocannabinoid lipid signals had made it challenging to determine the spatiotemporal specificity and dynamics of endocannabinoid signaling in vivo.
Brain endocannabinoid system has been implicated in various psychiatric and neurological disorders.
The researchers in this review discuss new novel technologies that helped unravel insights into endocannabinoid signaling and the role of hippocampus place cells on cannabinoid-sensitive inhibition.
They also evaluate the role of cannabinoid regulation of synapses in vivo and in other brain circuits in both health and disease.
