Molecular mechanisms of endometriosis and comorbidities
Endometriosis, traditionally classified as a gynecological condition, is increasingly recognized as a chronic systemic disease or syndrome, frequently associated with inflammatory and autoimmune comorbidities.
Shared genetic and molecular pathways may underlie the link between endometriosis and its associated comorbid conditions.
Pain centralization, neuroimmune crosstalk, and chronic stress mechanisms contribute significantly to reduced quality of life and are often accompanied by overlapping pain syndromes.
The presence of inflammatory and autoimmune comorbidities has important implications for diagnosis and treatment, underscoring the need for a comprehensive diagnostic work-up and a personalized therapeutic strategy.
Effective management of endometriosis requires a multidisciplinary approach that goes beyond traditional hormonal or surgical interventions and incorporates physical, psychological, and immune-modulating support.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00211-4
