Human iPSC-microglia to deliver disease-modifying proteins to the brain

As delivering therapeutic proteins into the brain is challenging, the researchers tested if human induced pluripotent stem cell (iPSC)-microglia (iMG) could enable brain-wide and pathology-responsive delivery of therapeutic cargo. They expressed the Aβ-degrading enzyme neprilysin in the iPSC-iMG.

They show that engineered iMG was pathology-responsive and enabled CNS-wide delivery of therapeutic proteins. Neprilysin delivered by microglia lowersed inflammation, dystrophic neurites, and plasma NfL

Their findings suggest that iMG could offer a promising new platform technology to deliver biological therapeutics throughout the brain.

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00099-2

https://sciencemission.com/iMG-delivery-of-disease-modifying-proteins