How immune aging impairs muscle regeneration
Aging may lead to challenges in muscle regeneration.
The researchers show that muscle aging alters the amplification of all niche cells with prominent phenotypes in macrophages.
They also demonstrate that each cell type responds to aging in a specific manner. Molecular profiling of muscle stem cells and their cellular niche uncovers specific profiles in old versus young muscle.
The authors observed that macrophages have an altered expression of Selenoprotein P (Sepp1) that is required for muscle regeneration. Macrophage-specific deletion of Sepp1 is sufficient to impair the acquisition of their restorative profile and causes inefficient skeletal muscle regeneration.
https://www.embopress.org/doi/full/10.1038/s44319-025-00516-3
