The macrophage disappearance reaction

The macrophage disappearance reaction is applicable across tissues and disease contexts. 

Macrophage disappearance reaction occurs in both resident and recruited macrophages to serve distinct purposes.

Macrophage disappearance reaction can occur via a spectrum of modalities, including distinct cell death pathways and (de)differentiation.

Each modality of the macrophage disappearance reaction alters the tissue niche in unique ways, regulating tissue responses.

The loss of tissue-resident macrophage homeostatic identity appears to be a key feature of tissue-resident macrophage activation.

 A better understanding of the mechanisms of the macrophage disappearance reaction will better inform decisions regarding the use of macrophage-based therapies in the clinic.

https://www.cell.com/trends/immunology/fulltext/S1471-4906(26)00072-4

https://sciencemission.com/macrophage-disappearance-reaction