Role of ribonuclease angiogenin in cross-regulates different gene expression processes

The activities of multifunctional ribonucleases on diverse RNA substrates, often in distinct cellular compartments, enable crosstalk between different aspects of gene expression to coordinate multifaceted reprograming in response to cellular stresses. 

Angiogenin has emerged as a stress sensitive, prototypical multifunctional ribonuclease with roles in regulating ribosomal DNA transcription and translation, as well as in the production of regulatory tRNA-derived small RNAs.

Dynamic alteration of angiogenin expression and subcellular localization in response to, for example, oxidative stress, triggers a dramatic change in the target spectrum of the ribonuclease.

New mechanistic insights into the regulation of angiogenin by ribonuclease/ angiogenin inhibitor 1, ribosomes, and phosphorylation provide bases for the development of therapeutics against neovascularization-associated diseases such as cancer and neurodegenerative disorders.

https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(26)00099-X

https://sciencemission.com/angiogenin-regulates-different-gene-expression-processes