Dr. Christopher Gregg, PhD

Assistant Professor, Neurobiology and Anatomy,
Adjunct Assistant Professor, Human Genetics,
University of Utah, Salt Lake City, UT , USA

Hangout Title: “Nongenetic allele-specific effects shape cellular gene expression in the mammalian brain”
Hangout Schedule:
May 17:12 pm MST, 1 pm CST,  2 pm EST, 11 am PST, 11.30 pm IST



Christopher




RESEARCH OVERVIEW

A major goal of our research is to uncover novel genetic and epigenetic mechanisms in the brain that regulate motivated behaviors. Alterations to motivated behaviors occur in a wide range of disorders, including anxiety disorders, major depression, addiction, bipolar disorder, autism spectrum disorders and eating disorders. Motivated beahviors involve opposing behavioral drives, such as hunger and satiety, reward and aversion, sleep and wake, or social and anti-scoial behaviors. The Gregg Lab is developing novel approaches to study complex motivated behaviors and to uncover functionally antagonistic pathways that regulate opposing motivational states. Our goal is to develop approaches to engineer specific patterns of behavior and to develop novel strategies to diagnose and treat complex psychiatric disorders. We are developing novel computation, genomics genome engineering and behavioral approaches to achieve these goals.


Selected Publications
Journal Article
  • High-resolution analysis of parent-of-origin allelic expression in the mouse brain.Gregg C, Zhang J, Weissbourd B, Luo S, Schroth GP, Haig D, Dulac C (2010). High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science, 329(5992), 643-8.
  • Sex-specific parent-of-origin allelic expression in the mouse brain.Gregg C, Zhang J, Butler JE, Haig D, Dulac C (2010). Sex-specific parent-of-origin allelic expression in the mouse brain. Science, 329(5992), 682-5.
  • Gregg C (2009). Pregnancy, Prolactin and White Matter Regeneration. Journal of Neurological Sciences, 285(1-2), 22-7.
  • White matter plasticity and enhanced remyelination in the maternal CNS.Gregg C, Shikar V, Larsen P, Mak G, Chojnacki A, Yong VW, Weiss S (2007). White matter plasticity and enhanced remyelination in the maternal CNS. J Neurosci, 27(8), 1812-23.
  • Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior.Mak GK, Enwere EK, Gregg C, Pakarainen T, Poutanen M, Huhtaniemi I, Weiss S (2007). Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior. Nat Neurosci, 10(8), 1003-11.
  • Kolb B, Morshead C, Gonzalez C, Kim M, Gregg C, Shingo T, Weiss S (2006). Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. J Cereb Blood Flow Metab, 27(5), 983-97.
  • Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo.Ohta S, Gregg C, Weiss S (2006). Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo. J Neurosci Res, 84(6), 1177-86.
  • CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain.Gregg C, Weiss S (2005). CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development, 132(3), 565-78.
  • Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination.Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S (2004). Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci, 24(38), 8354-65.
  • Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin.Shingo T, Gregg C, Enwere E, Fujikawa H, Hassam R, Geary C, Cross JC, Weiss S (2003). Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science, 299(5603), 117-20.
  • Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S (2003). Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci, 23(5), 1730-41.
  • Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells.Gregg C, Weiss S (2003). Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells. J Neurosci, 23(37), 11587-601.
Review
  • Gregg C (2014). Known unknowns for allele-specific expression and genomic imprinting effects. [Review]. F1000Research, 4(6), 75-77.
  • Gregg C (2010). Eppendorf winner. Parental Control Over The Brain. [Review]. Science, 330(6005), 770-1.
  • Gregg C (2009). Pregnancy, Prolactin and White Matter Regeneration. [Review]. Journal of Neurological Sciences, 285(1-2), 22-7.
  • Radial glial cells as neuronal precursors: the next generation?Gregg CT, Chojnacki AK, Weiss S (2002). Radial glial cells as neuronal precursors: the next generation? [Review]. J Neurosci Res, 69(6), 708-13.
  • Neural stem cells of the mammalian forebrain.Gregg CT, Shingo T, Weiss S (2001). Neural stem cells of the mammalian forebrain. [Review]. Symp Soc Exp Biol, (53), 1-19.
  • Book Chapter
  • Bonthuis P and Gregg C (2015). Decoding the Transcriptome of Neuronal Circuits. In Adam Douglass (Ed.), New Techniques in Systems Neuroscience (pp. 29-56). New York: Springer.
  • Dulac, C and Gregg C (2013). Genomic imprinting in the Adult and Developing Brain. In: Multiple Origins of Sex Differences in Brain. In D.W. Pfaff and Y. Christen (Eds.), Research and Perspectives in Endocrine Interactions. Springer-Verlag Berlin Heidelberg.
  • Huang, WC and Gregg C (2013). Genomic Imprinting in the Mammalian Brain. In R Kageyama, T. Yamamori (Eds.), Cortical development: neural diversity and neocortical organization. Springer.
  • Gregg C, Shingo T, and Weiss S (2001). Neural Stem Cells of the Forebrain. In J.A. Miyan et al. (Ed.), Brain Stem Cells: Development and Regeneration. BIOS Scientific Publishers. Oxford.
Abstract
  • Huang WC, Ferris E, Cheng T, Hrndli CS, Gleason K, Tamminga C, Gregg C (2016). Non-genetic Allelic Effects in the Human Brain [Abstract]. Human Epigenetics & Disease. Keystone meeting. Seattle, WA, USA.
  • Huang WC, Ferris E, Cheng T, Hrndli CS, Gleason K, Tamminga C, Wagner JD, Boucher KM, Christian JL, Gregg C (2016). Diverse Non-genetic Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain [Abstract]. Human Epigenetics & Disease. Keystone Meeting. Seattle, WA, USA.
  • Patent
  • Huang WC, Ferris E, Gregg C (2017). Algorithm to identify non-genetic allelic effects using RNASeq. U.S. Patent No. Provisional. Washington, D.C.:U.S. Patent and Trademark Office.
  • Gregg C, Ferris E (2016). Methods for Detecting Rapidly Processed Introns to Evaluate Allelic Expression. U.S. Patent No. 62/494,162 (July 29, 2016). Washington, D.C.:U.S. Patent and Trademark Office.
  • Gregg C, Weiss S (2009). Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin. U.S. Patent No. 7,534,765. Washington, D.C.:U.S. Patent and Trademark Office.
  • Weiss S, Gregg C, Davidoff A, Tucker J (2009). Continuous dosing regimes for neural stem cell proliferating agents and neural stem cell differentiating agents. U.S. Patent No. 0081205 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  • Weiss S, Gregg C, Davidoff A, Tucker J (2008). Dosing regimes for neural stem cell proliferating agents for the treatment of neurological disorders. U.S. Patent No. 0039389 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  • Weiss S, Gregg C (2006). Production of radial glial cells. U.S. Patent No. 7,033,995 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Weiss S, Enwere E, Andersen L, Gregg C (2005). Pheromones and the lutenizing hormone for inducing proliferation of neural stem cells and neurogenesis. U.S. Patent No. 0245436 A1. Washington, D.C.:U.S. Patent and Trademark Office.