Index - Sciencemission

Science Hangouts

Dimerization and activation of receptor tyrosine kinases: insights from quantitative fluorescence studies

Science Hangouts

Dimerization and activation of receptor tyrosine kinases: insights from quantitative fluorescence studies

14909

Primate Brain Expansion: Nature’s social experiments with gene, cell and anatomical novelty

Science Hangouts

Primate Brain Expansion: Nature’s social experiments with gene, cell and anatomical novelty

24

Systems Biology & Medicine: Markers, Mechanisms and Pathways

Science Hangouts

Systems Biology & Medicine: Markers, Mechanisms and Pathways

24

Science News Highlights

Glycolytic enzyme hexokinase-2 and brain disorders

News highlights

Glycolytic enzyme hexokinase-2 and brain disorders

9

Allergic Rhinitis

News highlights

Allergic Rhinitis

12

Large language models homogenizing effect on human expression and thought

News highlights

Large language models homogenizing effect on human exp...

11

News

Loss of Y chromosome in men could be early warning sign of cancer

Loss of Y chromosome in men could be early warning...

14

Autism-risk mutations reveal two opposing patterns of brain gene activity

Autism-risk mutations reveal two opposing patterns...

12

Structural basis of metabotropic glutamate receptor coupling with beta-arrestins

Structural basis of metabotropic glutamate recept...

21

Anti-seizure drug fights aggressive childhood brain tumors

Anti-seizure drug fights aggressive childhood brai...

27

The genetic code behind psoriasis cracked

The genetic code behind psoriasis cracked

26

TRPM2 is a direct transducer for chronic pain

TRPM2 is a direct transducer for chronic pain

20

AI language models for aging biology

AI language models for aging biology

34

Intermittent fasting shows promise in slowing Huntington’s disease progression

Intermittent fasting shows promise in slowing Hunt...

26

A bile acid shows potential for reducing liver fat

A bile acid shows potential for reducing liver fat

28

A molecular bridge connects two small GTPase pathways in plants

A molecular bridge connects two small GTPase pathw...

21

A generalist AI tool for abdominal CT diagnosis

A generalist AI tool for abdominal CT diagnosis

27

How bacteria pump an antibiotic out of their cells

How bacteria pump an antibiotic out of their cells

30

Rare inherited EGFR mutation linked to increased lung cancer risk

Rare inherited EGFR mutation linked to increased l...

24

Autism-risk mutations reveal two opposing patterns of brain gene activity

Autism-risk mutations reveal two opposing patterns...

12

TRPM2 is a direct transducer for chronic pain

TRPM2 is a direct transducer for chronic pain

20

Intermittent fasting shows promise in slowing Huntington’s disease progression

Intermittent fasting shows promise in slowing Hunt...

26

Locus coeruleus noradrenaline neurons mapped!

Locus coeruleus noradrenaline neurons mapped!

56

Psychedelics and anesthetics create mirror image patterns in the brain

Psychedelics and anesthetics create mirror image p...

36

Astrocyte cilium and stress behavior

Astrocyte cilium and stress behavior

75

Inhibitory brain circuits suppress glioblastoma growth

Inhibitory brain circuits suppress glioblastoma gr...

107

Linking deep-sleep loss to Alzheimer’s-related protein buildup

Linking deep-sleep loss to Alzheimer’s-related pro...

71

How APOE4 variant causes brain damage in Alzheimer’s disease

How APOE4 variant causes brain damage in Alzheime...

59

Cortical neurons involved in sleep identified!

Cortical neurons involved in sleep identified!

71

Using noise to regulate information flow in neural networks

Using noise to regulate information flow in neural...

58

How can music help us recover from stress?

How can music help us recover from stress?

79

Neural mechanisms of brain multitasking

Neural mechanisms of brain multitasking

86

Loss of Y chromosome in men could be early warning sign of cancer

Loss of Y chromosome in men could be early warning...

14

Anti-seizure drug fights aggressive childhood brain tumors

Anti-seizure drug fights aggressive childhood brai...

27

Reprogramming immune cells to boost glioblastoma chemotherapy

Reprogramming immune cells to boost glioblastoma c...

43

Pancreatic cancer uses blood-clotting system to evade immune attack

Pancreatic cancer uses blood-clotting system to ev...

33

Childhood chemotherapy leaves a lasting mutational footprint in healthy tissues

Childhood chemotherapy leaves a lasting mutational...

55

Region-specific brain tumors from gene mutations

Region-specific brain tumors from gene mutations

76

Molecular mechanism that helps aggressive colorectal cancer to spread

Molecular mechanism that helps aggressive colorect...

79

Tumor-liver interplay in cancer progression

Tumor-liver interplay in cancer progression

98

A tumor-liver interplay in colorectal cancer cachexia

A tumor-liver interplay in colorectal cancer cachexia

86

Metastatic triple-negative breast cancer regulated by miRNA

Metastatic triple-negative breast cancer regulated...

87

‘Molecular glue’ turns a cancer driver into a built-in kill switch

‘Molecular glue’ turns a cancer driver into a buil...

96

Gastrointestinal cancer detection using mouth to gut microbe signatures

Gastrointestinal cancer detection using mouth to g...

106

Amino acid metabolism rewiring leads to hormone therapy resistance in prostate cancer

Amino acid metabolism rewiring leads to hormone th...

99

How obesity enhances breast cancer risk?

How obesity enhances breast cancer risk?

49

Mechanism of obesity relapse

Mechanism of obesity relapse

133

Stress hormone timing creates a different kind of obesity

Stress hormone timing creates a different kind of ...

102

Ketogenic diet boosts liver health in addition to weight loss

Ketogenic diet boosts liver health in addition to ...

95

Short bursts of physical activity promote metabolic health better than moderate-intensity exercise

Short bursts of physical activity promote metaboli...

486

Gut microbiota can predict risk of type 2 diabetes years before it develops

Gut microbiota can predict risk of type 2 diabetes...

161

Epigenetic drugs could protect blood vessels in obesity and diabetes

Epigenetic drugs could protect blood vessels in ob...

185

Father’s obesity may lead to mitochondrial disfunction in children

Father’s obesity may lead to mitochondrial disfunc...

216

Weight-loss drugs inhibit brain’s reward system

Weight-loss drugs inhibit brain’s reward system

254

Obesity leaves a lasting memory in immune cells

Obesity leaves a lasting memory in immune cells

246

A new circadian lipid trafficking mechanism in liver

A new circadian lipid trafficking mechanism in liver

223

DNA methylation in islet cells in human ageing and diabetes

DNA methylation in islet cells in human ageing and...

254

GLP-1 medicine improves liver health independent of weight loss

GLP-1 medicine improves liver health independent o...

255

AI language models for aging biology

AI language models for aging biology

34

A generalist AI tool for abdominal CT diagnosis

A generalist AI tool for abdominal CT diagnosis

27

4D AI models predict how mitochondria respond to drug treatment

4D AI models predict how mitochondria respond to d...

31

A new genomic language model to spot genetic variants

A new genomic language model to spot genetic variants

95

Mapping the protein universe by uniting sequence and structure

Mapping the protein universe by uniting sequence a...

91

Proteomic signatures in children blood may provide clues to cardiometabolic diseases later in life

Proteomic signatures in children blood may provide...

51

AI finds hidden human proteins and their function

AI finds hidden human proteins and their function

193

Mammalian genes can combine to make previously unknown mRNAs, proteins

Mammalian genes can combine to make previously unk...

170

Taste connectome of adult Drosophila

Taste connectome of adult Drosophila

65

Proteomics and AI identify plasma biomarkers for vasculitis

Proteomics and AI identify plasma biomarkers for v...

55

Defining the degradability capability of protein degraders

Defining the degradability capability of protein d...

84

Tissue-specific aging signatures using histology and AI

Tissue-specific aging signatures using histology a...

148

AI based imaging to see tumor boundaries in 3D within 30 minutes

AI based imaging to see tumor boundaries in 3D wit...

109

Protein-based data storage

Protein-based data storage

198

Quantification of tandem repeats in native RNA

Quantification of tandem repeats in native RNA

191

Microrobotics technology to help transform cancer treatments of the future

Microrobotics technology to help transform cancer ...

201

Nanoparticles hijack skull immune cells to bypass the blood-brain barrier for brain drug delivery

Nanoparticles hijack skull immune cells to bypass ...

349

Revealing the cell’s nanocourier at work!

Revealing the cell’s nanocourier at work!

266

AI-generated sensors open new paths for early cancer detection

AI-generated sensors open new paths for early canc...

309

Stabilizing synthetic gene circuits in liquid condensates

Stabilizing synthetic gene circuits in liquid cond...

366

Magnetically guided microrobots for targeted drug delivery

Magnetically guided microrobots for targeted drug ...

356

Nanobody-based recombinant antivenom

Nanobody-based recombinant antivenom

319

First artificial neurons that could directly communicate with living cells

First artificial neurons that could directly commu...

364

New insight into ion transport via angstrom-scale two-dimensional channels

New insight into ion transport via angstrom-scale ...

323

Brain probe powerfully records neural circuits during behavior

Brain probe powerfully records neural circuits dur...

401

A novel vesicle-based method to capture the native structure of membrane proteins

A novel vesicle-based method to capture the native...

389

Tendon and ligament stem cells identified!

Tendon and ligament stem cells identified!

75

AI identifies regulatory hub for aging in hematopoietic stem cells

AI identifies regulatory hub for aging in hematopo...

90

Abnormal differentiation of fetal neural progenitor cells causes autistic-like behavior

Abnormal differentiation of fetal neural progenito...

64

Microglial cells from patients with genetic and sporadic frontotemporal dementia differ from each other

Microglial cells from patients with genetic and sp...

101

Brain organoids survive and mature for over 5 years

Brain organoids survive and mature for over 5 years

85

A new organoid model of the cerebral cortex

A new organoid model of the cerebral cortex

108

Human heart valve-like tissues from pluripotent stem cells

Human heart valve-like tissues from pluripotent st...

99

A novel 3D brain tissue model

A novel 3D brain tissue model

133

EV secretome to treat cardiac fibrosis

EV secretome to treat cardiac fibrosis

108

Preventing excessive stem cell proliferation via cell junction proteins

Preventing excessive stem cell proliferation via c...

107

Protein excess tips the balance of cellular health

Protein excess tips the balance of cellular health

191

Reverting aged cells to stem cells

Reverting aged cells to stem cells

245

Multipotent progenitors protect blood cell production and function

Multipotent progenitors protect blood cell product...

134

The genetic code behind psoriasis cracked

The genetic code behind psoriasis cracked

26

Rare inherited EGFR mutation linked to increased lung cancer risk

Rare inherited EGFR mutation linked to increased l...

24

Eight genetic ‘fingerprints’ for aggressive prostate cancer

Eight genetic ‘fingerprints’ for aggressive prosta...

27

Feeding mice fewer calories reduce DNA mutations

Feeding mice fewer calories reduce DNA mutations

45

Generational chromosome repair!

Generational chromosome repair!

47

Gene defects linked to primary ciliary dyskinesia

Gene defects linked to primary ciliary dyskinesia

46

Is our personality written in our genes?

Is our personality written in our genes?

149

Gene expression and metabolomics in aging women

Gene expression and metabolomics in aging women

67

How chromosomes find their partners

How chromosomes find their partners

130

New gene activation tool!

New gene activation tool!

95

Role of Vitamin B12 in spliceosomopathy

Role of Vitamin B12 in spliceosomopathy

100

First complete marmoset genome

First complete marmoset genome

104

Mechanisms of α-ketoglutarate signaling to chromatin

Mechanisms of α-ketoglutarate signaling to chromatin

148

A bile acid shows potential for reducing liver fat

A bile acid shows potential for reducing liver fat

28

Blocking a protein may reduce buildup of harmful aging cells

Blocking a protein may reduce buildup of harmful a...

69

Gut cell turnover is determined by nutrient quantity and not quality!

Gut cell turnover is determined by nutrient quanti...

125

Mitochondrial complex I dysfunction treated with hypoxia

Mitochondrial complex I dysfunction treated with h...

155

How life experiences can shape aging in multiple tissues

How life experiences can shape aging in multiple t...

157

Kidney injury repair using a humanized monoclonal antibody

Kidney injury repair using a humanized monoclonal ...

144

A molecular linchpin for muscle health identified!

A molecular linchpin for muscle health identified!

147

Daily multivitamin use may slow biological aging

Daily multivitamin use may slow biological aging

251

A key hormonal circuit in the kidneys

A key hormonal circuit in the kidneys

273

Remodeling of the ceramide backbone prevents kidney injury

Remodeling of the ceramide backbone prevents kidne...

268

Skin protein found to use physical tension to control tissue growth

Skin protein found to use physical tension to cont...

286

Unknown organelle inside our cells discovered!

Unknown organelle inside our cells discovered!

602

Uncovering the secret of long-lived stem cells

Uncovering the secret of long-lived stem cells

587

Atherosclerosis is an autoimmune disease!

Atherosclerosis is an autoimmune disease!

35

Mechanism behind dangerous blood-clotting disorder uncovered!

Mechanism behind dangerous blood-clotting disorder...

53

Stressed mitochondria protect the heart!

Stressed mitochondria protect the heart!

65

Mechanism of diabetic drug mediated heart failure protection

Mechanism of diabetic drug mediated heart failure ...

81

Capillaries and not arteries give rise to backup blood vessels

Capillaries and not arteries give rise to backup ...

83

Hypothalamus-heart-tumor axis in environmental eustress protection against cardiotoxicity and tumor growth

Hypothalamus-heart-tumor axis in environmental eus...

110

Coordinating the development of heart muscle and vasculature

Coordinating the development of heart muscle and v...

99

Breaking down barriers to cardiac regeneration

Breaking down barriers to cardiac regeneration

108

Low heart disease–linked transcription factor dismantles DNA organization

Low heart disease–linked transcription factor dism...

132

Molecular pathway driving aortic disease in Marfan syndrome

Molecular pathway driving aortic disease in Marfan...

128

Molecular mechanics behind heart cell restructuring revealed

Molecular mechanics behind heart cell restructurin...

169

Alternative splicing in heart development and disease

Alternative splicing in heart development and disease

152

Age does not appear to drive cardiovascular risk in pregnancy

Age does not appear to drive cardiovascular risk i...

138

Alpha-1 antitrypsin emerges as a potential target for preventing spontaneous preterm birth

Alpha-1 antitrypsin emerges as a potential target ...

52

Postbiotics may boost female fertility

Postbiotics may boost female fertility

113

X chromosome inactivation in immune cells

X chromosome inactivation in immune cells

126

Brain development risks associated with certain medications during pregnancy

Brain development risks associated with certain me...

128

Mothers’ prenatal immunity shapes lifelong resistance to gum disease

Mothers’ prenatal immunity shapes lifelong resista...

180

Aging human breast atlas reveals cancer susceptibility

Aging human breast atlas reveals cancer susceptib...

195

Linking fertility with immune cells in the brain

Linking fertility with immune cells in the brain

236

Genomic reorganization at the transition to gametogenesis

Genomic reorganization at the transition to gameto...

214

Activating dormant eggs to restore fertility

Activating dormant eggs to restore fertility

272

sncRNAs in sperm aging

sncRNAs in sperm aging

336

Modeling human embryo implantation in vitro

Modeling human embryo implantation in vitro

272

How reproductive organs form

How reproductive organs form

370

Do hormones explain why women experience more gut pain?

Do hormones explain why women experience more gut ...

281

Structural basis of metabotropic glutamate receptor coupling with beta-arrestins

Structural basis of metabotropic glutamate recept...

21

Alternative pathway for transthyretin denaturation!

Alternative pathway for transthyretin denaturation!

31

How blood cells release key signaling lipid

How blood cells release key signaling lipid

53

Transcription of eight letter codon!

Transcription of eight letter codon!

65

How bacteria assemble outer membrane proteins

How bacteria assemble outer membrane proteins

68

Regulation of protein transport from ER to Golgi

Regulation of protein transport from ER to Golgi

55

Why some misfolded proteins do not undergo proteasomal degradation

Why some misfolded proteins do not undergo protea...

62

New method to synthesize proteins by modifying tRNAs

New method to synthesize proteins by modifying tRNAs

77

Key cancer-related receptor is regulated by glycan interactions on cell surfaces

Key cancer-related receptor is regulated by glycan...

86

Modified tRNA rescues nonsense mutations in cystic fibrosis

Modified tRNA rescues nonsense mutations in cystic...

79

Altered mitochondrial metabolism in senescent cells promote inflammation in aged cells

Altered mitochondrial metabolism in senescent cell...

90

Native RNA Polymerase II Transcription Complexes structure revealed!

Native RNA Polymerase II Transcription Complexes s...

102

Membrane protein quality control at the ribosome

Membrane protein quality control at the ribosome

64

How bacteria pump an antibiotic out of their cells

How bacteria pump an antibiotic out of their cells

30

Highly potent compound that blocks Ebola virus entry discovered!

Highly potent compound that blocks Ebola virus ent...

40

Despite antibiotic treatment why strep throat can linger?

Despite antibiotic treatment why strep throat can ...

68

Hidden weak spot in how bacteria build the tails

Hidden weak spot in how bacteria build the tails

32

Lung fibrosis from a bacterial protein fragment

Lung fibrosis from a bacterial protein fragment

54

A gut bacterium and its metabolite found to delay aging

A gut bacterium and its metabolite found to delay ...

97

Urinary microbiome can make androgens!

Urinary microbiome can make androgens!

88

Methylation puts parasites in motion

Methylation puts parasites in motion

66

A skin fungus hides in hair follicles!

A skin fungus hides in hair follicles!

168

New antibiotic mechanisms discovered!

New antibiotic mechanisms discovered!

205

Antibiotic-tolerant bacteria rely on a hidden survival strategy

Antibiotic-tolerant bacteria rely on a hidden surv...

124

Understanding sepsis infections using cellular behavioromics

Understanding sepsis infections using cellular beh...

112

Antibiotic resistant gene found in Australian soil

Antibiotic resistant gene found in Australian soil

127

Limits of “precise” gene editing in human embryos

Limits of “precise” gene editing in human embryos

65

Regulatory logic of neuronal differentiation

Regulatory logic of neuronal differentiation

56

Signaling pathway controlling brain development timing identified!

Signaling pathway controlling brain development ti...

55

Role of glycolysis and pentose phosphate pathway in the development of human cortex

Role of glycolysis and pentose phosphate pathway i...

62

4D map of the hair follicle organogenesis

4D map of the hair follicle organogenesis

68

How folic acid protects the developing brain and spinal cord

How folic acid protects the developing brain and s...

76

A lipid regulator of Sonic hedgehog signaling influences heart and lung development

A lipid regulator of Sonic hedgehog signaling infl...

107

Role for NANOG in human embryogenesis

Role for NANOG in human embryogenesis

152

The role of signaling pathways timing in brain development

The role of signaling pathways timing in brain dev...

159

Early brain activity shape vocal circuits!

Early brain activity shape vocal circuits!

146

Mechanism of collective cellular migration and invasion

Mechanism of collective cellular migration and inv...

142

A protein directs neuronal migration in the embryonic brain

A protein directs neuronal migration in the embryo...

169

E. coli and 'good' bacteria balanced by breastmilk in baby gut microbiomes

E. coli and 'good' bacteria balanced by breastmilk...

153

A molecular bridge connects two small GTPase pathways in plants

A molecular bridge connects two small GTPase pathw...

21

New gene-editing tool for hard-to-breed perennial crops

New gene-editing tool for hard-to-breed perennial ...

56

Increasing plants synthesis of lignin and starch

Increasing plants synthesis of lignin and starch

71

A fungal protein that causes leaf loss in crops discovered

A fungal protein that causes leaf loss in crops di...

82

Phytochemicals, microbiome and health benefits

Phytochemicals, microbiome and health benefits

161

Programmable design of synthetic plant immune receptors

Programmable design of synthetic plant immune rece...

138

‘Saprotropism’ helps roots avoid decaying plant matter

‘Saprotropism’ helps roots avoid decaying plant ma...

142

Mechanisms for plant cell stability in drought

Mechanisms for plant cell stability in drought

134

Plants reduce iron uptake when stressed

Plants reduce iron uptake when stressed

135

Cure for dry eye disease

Cure for dry eye disease

169

Garlic kills mosquitoes’ mood too!

Garlic kills mosquitoes’ mood too!

179

A new mechanism of activation of plants immune defenses by soil bacteria

A new mechanism of activation of plants immune def...

196

Maintaining stability of the plant proteome and controlling stress responses

Maintaining stability of the plant proteome and co...

174

Why some people can fight infections better than others?

Why some people can fight infections better than o...

101

Restoring aging T cell function to fight cancer

Restoring aging T cell function to fight cancer

83

Gene circuits of human immunity

Gene circuits of human immunity

96

Cell proliferation protein promotes inflammation in aging cells

Cell proliferation protein promotes inflammation i...

90

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

A necroptotic-to-apoptotic signaling axis underlie...

103

Cellular stress sensor also acts as a cholesterol sensor in immune cells

Cellular stress sensor also acts as a cholesterol ...

72

Brain-to-liver pathway that protects against liver inflammation

Brain-to-liver pathway that protects against liver...

97

Transition from milk to solid food shapes immune system development

Transition from milk to solid food shapes immune s...

86

Malaria causes permanent damage to phagocytes in the spleen

Malaria causes permanent damage to phagocytes in t...

91

A critical immune pathway in systemic anaphylactic responses identified!

A critical immune pathway in systemic anaphylactic...

101

Blocking xenophagocytosis for interspecies organ generation

Blocking xenophagocytosis for interspecies organ g...

93

How autophagy helps to reduce inflammation

How autophagy helps to reduce inflammation

123

Leveraging COVID-19 immune memory into a weapon against cancer

Leveraging COVID-19 immune memory into a weapon ag...

96

New modular hydrogel plug-and-play platform

New modular hydrogel plug-and-play platform

81

Air-permeable hydrogels!

Air-permeable hydrogels!

136

Temperature behaves differently in the cell

Temperature behaves differently in the cell

135

Engineering faster, more effective blood clots

Engineering faster, more effective blood clots

125

Optical neural control by blood-catalyzed polymers

Optical neural control by blood-catalyzed polymers

168

Cell ratio control using synthetic circuits

Cell ratio control using synthetic circuits

191

Cellular mechano-sensation linked to gene enhancers!

Cellular mechano-sensation linked to gene enhancers!

265

Implant treats Type 1 diabetes by oxygenating insulin-producing cells

Implant treats Type 1 diabetes by oxygenating insu...

544

Protecting the biomolecules with simple peptides

Protecting the biomolecules with simple peptides

438

Trapping gut microbiota produced molecule to improve blood sugar levels

Trapping gut microbiota produced molecule to impro...

924

Converting urine into high-value bio-implant material

Converting urine into high-value bio-implant material

538

MetaFlowTrain to study ‘metabolic dialogue’ between microorganisms

MetaFlowTrain to study ‘metabolic dialogue’ betwee...

510

Printed skin to replace animal testing

Printed skin to replace animal testing

509

Rewiring ribosomes to specialize in one protein

Rewiring ribosomes to specialize in one protein

34

A Google-like search engine for single-cell RNA

A Google-like search engine for single-cell RNA

81

New CRISPR method to control protein production in cells

New CRISPR method to control protein production in...

88

Electronic skin for prosthetics to sense temperature and pressure

Electronic skin for prosthetics to sense temperatu...

67

Computer framework identifies disease driving genes in asthma

Computer framework identifies disease driving gene...

81

Viral RNA elements functional map!

Viral RNA elements functional map!

79

How proteins change shape and move

How proteins change shape and move

85

Cellular factors controlling nonviral genome editing efficiency identified!

Cellular factors controlling nonviral genome editi...

84

Next-gen patient-derived cancer models

Next-gen patient-derived cancer models

140

Mapping the 3D genome in rare immune cells

Mapping the 3D genome in rare immune cells

84

Glioblastoma isoform diversity mapping

Glioblastoma isoform diversity mapping

96

Metabolically activated molecular glue degrader platform

Metabolically activated molecular glue degrader pl...

136

New wearable ring tracks glucose, ketone and other biomarkers in sweat

New wearable ring tracks glucose, ketone and other...

533

How a mouse survives in one of Earth’s harshest environments

How a mouse survives in one of Earth’s harshest en...

151

Societal inequality linked to structural brain changes in children

Societal inequality linked to structural brain cha...

292

How gut bacteria change after exposure to pesticides

How gut bacteria change after exposure to pesticides

485

Fire smoke exposure impacts Immune system

Fire smoke exposure impacts Immune system

505

Global warming linked to dangerous sleep apnea

Global warming linked to dangerous sleep apnea

469

How the brain regulates emotions

How the brain regulates emotions

701

CLIMBING FIBRES AS TEACHING SIGNALS FOR ASSOCIATIVE CEREBELLAR LEARNING

CLIMBING FIBRES AS TEACHING SIGNALS FOR ASSOCIATIV...

552

More influence of environment than genetics in metacognitive abilities

More influence of environment than genetics in met...

551

Vitamin D regulates microbiome-dependent cancer immunity

Vitamin D regulates microbiome-dependent cancer im...

575

Vision plays a key role in sculpting brain development

Vision plays a key role in sculpting brain develop...

542

Without genetic mutations tumors are formed!

Without genetic mutations tumors are formed!

539

Link between dietary choices and brain health

Link between dietary choices and brain health

510

How the brain's arousal center also helps control visual attention

How the brain's arousal center also helps control ...

498

Research

Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer

Human Y chromosome pan-organ mapping reveals progr...

12

Configurational diversity of metabotropic glutamate receptor complexes with beta- arrestins

Configurational diversity of metabotropic glutama...

13

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta- arrestins

Structural basis of active state coupling of meta...

11

Hexokinase-2–glycolytic overload axis in brain disorders exacerbated by diabetes

Hexokinase-2–glycolytic overload axis in brain dis...

220

Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets

Integration of GWAS and single-cell analysis for p...

20

An open benchmark and language models for AI in aging biology

An open benchmark and language models for AI in ag...

21

The homogenizing effect of large language models on human expression and thought

The homogenizing effect of large language models o...

19

Allergic Rhinitis

Allergic Rhinitis

62

Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways

Hyodeoxycholic acid suppresses hepatic steatosis i...

27

REAP1/AtSWAP70 integrates RAB5 and ROP signalling during sexual reproduction

REAP1/AtSWAP70 integrates RAB5 and ROP signalling ...

18

Re-evaluation of Genotype-Phenotype Correlations in D-Bifunctional Protein Deficiency in a Phenotypically Diverse Cohort of 27 Natural History Study Participants

Re-evaluation of Genotype-Phenotype Correlations i...

28

Inhibiting Wnt/β-catenin-mTOR Signaling Enhances Porphyrin Clearance in Porphyrias with Hepatic Involvement

Inhibiting Wnt/β-catenin-mTOR Signaling Enhances P...

1112

Multi-Omic Evaluation of Glycosylation Restoration Therapy in SLC35A2-CDG

Multi-Omic Evaluation of Glycosylation Restoration...

23

Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer

Human Y chromosome pan-organ mapping reveals progr...

12

Configurational diversity of metabotropic glutamate receptor complexes with beta- arrestins

Configurational diversity of metabotropic glutama...

13

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta- arrestins

Structural basis of active state coupling of meta...

11

Hexokinase-2–glycolytic overload axis in brain disorders exacerbated by diabetes

Hexokinase-2–glycolytic overload axis in brain dis...

220

Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets

Integration of GWAS and single-cell analysis for p...

20

The homogenizing effect of large language models on human expression and thought

The homogenizing effect of large language models o...

19

Allergic Rhinitis

Allergic Rhinitis

62

Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways

Hyodeoxycholic acid suppresses hepatic steatosis i...

27

REAP1/AtSWAP70 integrates RAB5 and ROP signalling during sexual reproduction

REAP1/AtSWAP70 integrates RAB5 and ROP signalling ...

18

When minds become data: brain–computer interfaces and the future of mental privacy

When minds become data: brain–computer interfaces ...

810

Topographic structure and function of locus coeruleus noradrenaline neurons

Topographic structure and function of locus coerul...

530

Moving intentions from brains to machines

Moving intentions from brains to machines

37

Opposite network patterns of integration- segregation in psychedelic and sedated states of consciousness

Opposite network patterns of integration- segregat...

33

An open benchmark and language models for AI in aging biology

An open benchmark and language models for AI in ag...

21

Synonymous sequence design controls the folding, processing, and activity of the therapeutic protein ADAMTS13

Synonymous sequence design controls the folding, p...

30

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data

Whole-cell particle-based digital twin simulations...

28

4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning

4D spatiotemporal landscape of mitochondrial pheno...

33

Boosting genome editing in perennial plants by CRISPR-Combo mediated morphogenic gene activation

Boosting genome editing in perennial plants by CRI...

72

CRISPR genome editing in plants without tissue culture

CRISPR genome editing in plants without tissue cul...

168

Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission

Towards a proteomic plasma biomarker panel for dia...

275

Automated prototyping of genetic codes

Automated prototyping of genetic codes

276

Lysosome-targeted protein degradation platforms for spatiotemporally controlled degradation

Lysosome-targeted protein degradation platforms fo...

277

Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis

Combined multi-omics and multi-spectral profiling ...

206

Ultrafast and reference-free sequence discovery in single-cell data

Ultrafast and reference-free sequence discovery in...

96

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Genome-scale perturb-seq in primary human CD4+ T c...

76

TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation

TIGRa: An ultra-compact programmable activator ena...

3021

Breeding of Cotton

Breeding of Cotton

662

MOTOR & SENSORY PATHWAYS OF THE NERVOUS SYSTEM

MOTOR & SENSORY PATHWAYS OF THE NERVOUS SYSTEM

839

THALASSEMIA

THALASSEMIA

983

BASIC PRINCIPLES OF IMMUNOTHERAPY

BASIC PRINCIPLES OF IMMUNOTHERAPY

979

NMDA RECEPTORS

469

Neural Development

Neural Development

455

Transcription Factors

Transcription Factors

441

Interferons

395

RABIES

407

ANEMIA

400

Ubiquitin-mediated proteolysis

Ubiquitin-mediated proteolysis

393

Migraine

324

Dementia

413

Re-evaluation of Genotype-Phenotype Correlations in D-Bifunctional Protein Deficiency in a Phenotypically Diverse Cohort of 27 Natural History Study Participants

Re-evaluation of Genotype-Phenotype Correlations i...

28

Inhibiting Wnt/β-catenin-mTOR Signaling Enhances Porphyrin Clearance in Porphyrias with Hepatic Involvement

Inhibiting Wnt/β-catenin-mTOR Signaling Enhances P...

1112

Multi-Omic Evaluation of Glycosylation Restoration Therapy in SLC35A2-CDG

Multi-Omic Evaluation of Glycosylation Restoration...

23

Defining the Genotype-CRIM Status Relationship in a Large Cohort of 215 Patients with Infantile-onset Pompe Disease

Defining the Genotype-CRIM Status Relationship in ...

81

Growth Outcomes and Safety of Navepegritide in Children with Achondroplasia: Results of the ApproaCH Trial Open Label Extension

Growth Outcomes and Safety of Navepegritide in Chi...

729

Mitochondrial Function in Fibroblasts from a Patient with Congenital NAD Deficiency due to Biallelic NADSYN1 Variants

Mitochondrial Function in Fibroblasts from a Patie...

71

PROTEIN TARGETS OF CO2-DEPENDENT LYSINE CARBOXYLATION IN THE MOUSE BRAIN

PROTEIN TARGETS OF CO2-DEPENDENT LYSINE CARBOXYLAT...

125

EVIDENCES OF INTERLEUKIN 20 RECEPTOR A BLOCKADE BY RITONAVIRIN TRIPLE NEGATIVE BREAST CANCER CELLS

EVIDENCES OF INTERLEUKIN 20 RECEPTOR A BLOCKADE BY...

93

REDOX PROTEOMICS REVEALS A RECIPROCAL REDOX-METABOLIC COUPLING THAT REGULATES CIRCADIAN CLOCK

REDOX PROTEOMICS REVEALS A RECIPROCAL REDOX-METABO...

659

COPPER-DRIVEN REDOX MODULATION AMPLIFIES THYMOQUINONE- MEDIATED DNA DAMAGE, APOPTOSIS SIGNALING, AND TUMOR SUPPRESSION IN COLORECTALCANCER

COPPER-DRIVEN REDOX MODULATION AMPLIFIES THYMOQUIN...

288

PROTECTIVE EFFECT OF ENHANCED MITOCHONDRIAL TURNOVER BY POTENT SMALL MOLECULE INHIBITOR OF USP14

PROTECTIVE EFFECT OF ENHANCED MITOCHONDRIAL TURNOV...

3141

FINDING TROUBLE IN PAIRS: A SYNTHETIC GENETIC INTERACTION FRAMEWORK IN CHLAMYDOMONAS REINHARDTII

FINDING TROUBLE IN PAIRS: A SYNTHETIC GENETIC INTE...

233

NUCLEOCYTOPLASMIC TRANSPORT INHIBITION AS A POTENTIAL THERAPEUTIC TARGET IN ENDOMETRIAL CANCER

NUCLEOCYTOPLASMIC TRANSPORT INHIBITION AS A POTENT...

64

School Science

Disease Science

Gestational diabetes etiology and molecular mechanisms

Gestational diabetes etiology and molecular mechan...

525

Gestational diabetes therapeutics

Gestational diabetes therapeutics

622

Genetic factors in Gestational Diabetes

Genetic factors in Gestational Diabetes

575

C9ORF72 gene in Alzheimer’s disease

C9ORF72 gene in Alzheimer’s disease

916

Different types of Alzheimer's disease

Different types of Alzheimer's disease

667

How does Alzheimer's disease progress over time?

How does Alzheimer's disease progress over time?

603

Alzheimer’s therapeutics

Alzheimer’s therapeutics

733

Genetics of Alzheimer’s disease

Genetics of Alzheimer’s disease

617

Microglia in Alzheimer’s disease

Microglia in Alzheimer’s disease

625

Neuroinflammation in Alzheimer’s disease

Neuroinflammation in Alzheimer’s disease

566

Gut microbiota and Alzheimer’s disease

Gut microbiota and Alzheimer’s disease

560

APOE in Alzheimer’s

APOE in Alzheimer’s

786

Cellular and molecular mechanisms of Alzheimer’s disease

Cellular and molecular mechanisms of Alzheimer’s d...

713

C9ORF72 gene in Alzheimer’s disease

C9ORF72 gene in Alzheimer’s disease

916

Different types of Alzheimer's disease

Different types of Alzheimer's disease

667

How does Alzheimer's disease progress over time?

How does Alzheimer's disease progress over time?

603

Alzheimer’s therapeutics

Alzheimer’s therapeutics

733

Genetics of Alzheimer’s disease

Genetics of Alzheimer’s disease

617

Microglia in Alzheimer’s disease

Microglia in Alzheimer’s disease

625

Neuroinflammation in Alzheimer’s disease

Neuroinflammation in Alzheimer’s disease

566

Gut microbiota and Alzheimer’s disease

Gut microbiota and Alzheimer’s disease

560

APOE in Alzheimer’s

APOE in Alzheimer’s

786

Cellular and molecular mechanisms of Alzheimer’s disease

Cellular and molecular mechanisms of Alzheimer’s d...

713

Amyloid precursor protein in Alzheimer's disease

Amyloid precursor protein in Alzheimer's disease

564

Tau in Alzheimer’s disease

Tau in Alzheimer’s disease

722

Presenilin (PSEN) in Alzheimer’s

Presenilin (PSEN) in Alzheimer’s

503

Gestational diabetes etiology and molecular mechanisms

Gestational diabetes etiology and molecular mechan...

525

Gestational diabetes therapeutics

Gestational diabetes therapeutics

622

Genetic factors in Gestational Diabetes

Genetic factors in Gestational Diabetes

575